Our Science
Microgenesis is a biotechnology startup created by women for women, with the goal of helping find more natural and effective solutions to restore women's fertility potential.
Our History
Microgenesis was founded in 2020 by reproductive immunology researchers who spent 15 years studying the impact of systemic inflammation on fertility. Microgenesis’s* scientific research and advancements in cutting-edge technology provide functional tests and solutions. The Microgenesis test identifies 98 gut flora profiles that trigger immunological changes leading to reproductive conditions and tailors natural solutions that optimize health and fertility. Microgenesis technology identifies different epigenetic changes in the microbiome that contribute to the development of polycystic ovary syndrome, endometriosis, premature ovarian failure, autoimmunity, recurrent candidiasis, and vulvovaginitis. Based on the science and experiences of those who have followed its program, we can guide healthcare professionals and patients to identify and customize natural programs that restore reproductive potential and enhance feminine well-being based on each woman's unique needs.
Gut microbiota and reproductive health
We discovered the relationship between intestinal microbiota and fertility.
Our scientific team conducted a clinical study on the importance of women's health and the gut microbiome in recurrent implantation failure. We also concluded that each person's chemistry and microbiome are highly complex, completely unique, and constantly changing depending on the impact of environmental and dietary factors related to lifestyle and the city where each patient lives.
We studied 287 women with unexplained infertility between the ages of 27 and 52, with an average pregnancy rate of 1 and parity of 0, and an average of 10 years of trying to conceive. Before being studied, they underwent an average of four IVF cycles, half of them with donor oocytes. We found three types of gut and vaginal microbiome dysbiosis in 80% of them, compared to a control group of fertile women. After studying inflammatory markers associated with miRNAs secreted by immune cells in response to the absent microorganisms, we established different microgenesis profiles associated with infertility.
Influences of the microbiome
Learn more about expanding research and access scientific articles related to symptoms and conditions associated with an unhealthy microbiome.
INCLUDED -
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INFERTILITY
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MENORRHAGIA, AMENORRHEA AND DYSMENORRHEA
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RECURRENT URINARY TRACT INFECTIONS
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CONSTIPATION
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MIGRAINES
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AUTOIMMUNITY
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IRRITABLE BOWEL DISEASE
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ENDOMETRITIS AND ENDOMETRIOSIS
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Celiac disease
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HYPOTHYROIDISM AND AUTOIMMUNE THYROIDITIS (HASHIMOTO)
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POLYCYSTIC OVARY
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INSULIN RESISTANCE
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DYSLIPIDEMIA
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HYPOVITAMINOSIS D
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ABDOMINAL DISTENSION/GASTRITIS
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FOOD INTOLERANCES
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ANEMIA
Micro RNAs
Cutting-edge technology
These miRNAs affect fertility through inflammatory processes and can be analyzed using a vaginal sample obtained with a noninvasive swab.
We found that the gut microbiota of women with unexplained infertility is different from that of fertile women. These changes are associated with a subclinical inflammatory process that could impact pregnancy rates.
The microorganisms in our microbiota are responsible for metabolizing nutrients and act as a protective barrier. When the microbiota is altered, it affects metabolic immune responses. A weakened immune system can cause systemic inflammation, which makes pregnancy difficult and can lead to miscarriages.
What happens if the intestinal microbiota is altered?
Leaky gut syndrome is a condition that occurs when the intestinal microbiota is altered. This loosens the connection between the cells of the intestinal barrier, allowing toxins, bacteria, and other substances that shouldn't cross this barrier to reach the bloodstream. This causes inflammation and a weakened immune system. Symptoms can include fatigue, acne, eczema, constipation, mental health issues, problems with nutrient absorption, and infertility, among others. Studies link intestinal dysbiosis with diseases such as endometriosis and thyroid autoimmunity.
Gut dysbiosis is associated with insulin resistance as a survival strategy that is essential during fasting and in the fight against infections. The relationship with certain dietary components, and in particular with the gut microbiota, points to new paradigms in understanding the pathophysiology of polycystic ovary syndrome and metabolic syndrome.
OUR LAB
OUR LAB
